Claudette Colbert
Cleopatra
Warren William
Julius Caesar
Henry Wilcoxon
Marc Antony
Joseph Schildkraut
King Herod
Ian Keith
Octavian
Gertrude Michael
Calpurnia
C. Aubrey Smith
Enobarbus
Irving Pichel
Apollodorus
Arthur Hohl
Brutus
Edwin Maxwell
Casca
Leonard Mudie
Pothinos
Ferdinand Gottschalk
Glabrio (scenes deleted)
Claudia Dell
Octavia
Harry Beresford
Soothsayer
Jayne Regan
Lady Vesta
William Farnum
Lepidus
Lionel Belmore
Fidius
Florence Roberts
Lady Flora
Richard Alexander
General Philodemas
William V. Mong
Court Physician
Robert Warwick
General Achillas
George Walsh
Courier
Wedgwood Nowell
Scribe
Robert Seiter
Aelius
Edgar Dearing
Convict
John Carradine
Roman Citizen/Party Guest/Soldier (uncredited) (voice)
Wilfred Lucas
Roman Greeting Antony (uncredited)
David Niven
Slave (uncredited)
Olga Celeste
Slave Girl (uncredited)
Ynez Seabury
Undetermined Role (uncredited)
Carlyle Blackwell Jr.
Undetermined Role (uncredited)
Marjorie Bonner
Roman Girl (uncredited)
Edmund Burns
Roman (uncredited)
Horace B. Carpenter
Roman (uncredited)
Neal Hart
Slave (uncredited)
Shep Houghton
Roman Soldier (uncredited)
Julanne Johnston
Undetermined Role (uncredited)
Darby Jones
Fan Bearer (uncredited)
Lillian Leighton
Onlooker at Procession (uncredited)
Mary MacLaren
Roman Woman (uncredited)
John Merton
Roman Guard (uncredited)
Juanita Moore
Dancer / Slave Girl (uncredited)
Jack Mulhall
Roman Greeting Antony (uncredited)
Hal Price
Onlooker at Procession (uncredited)
John Roy
Roman Soldier (uncredited)
Jack Rutherford
Drussus (uncredited)
Phillips Smalley
Roman (uncredited)
Dale Van Sickel
Roman Soldier (uncredited)
Bryant Washburn
Undetermined Role (uncredited)
Blue Washington
Nubian Guard (uncredited)