Will Ferrell
Sherlock Holmes
John C. Reilly
Dr. John Watson
Rebecca Hall
Dr. Grace Hart
Kelly Macdonald
Mrs. Martha Hudson
Rob Brydon
Inspector Lestrade
Lauren Lapkus
Millie
Pam Ferris
Queen Victoria
Ralph Fiennes
Prof. James Moriarty / Jacob Musgrave
Adam Scherr
Brawn
Kieran O'Brien
PC Smalls
Noah Jupe
Doxy
Bella Ramsey
Flotsam
Scarlet Grace
Pickle
Billy Jenkins
Mud Fog
Michael Culkin
The Judge
Jana Pérez
Lestrade's Wife
Wolf Roth
Sigmund Freud
Paul Cassidy
Charlie Chaplin
Ben Lee
Houdini
Bronson Webb
Jonathan Nightingale
Billy Zane
Billy Zane
Jason Thorpe
Butler
Robert Cawsey
Waiter
Oliver Maltman
Telegraph Operator
David Stoller
Hudson's Guard
Lilly Aspell
Newschild
Ethan Rouse
Newschild
Jamie Baughan
Titanic Ship Officer Liaison
Jess Liaudin
Hangman
Daniel Fearn
Drooling Man Companion
Martin Bishop
Priest
Gerard Monaco
Titanic Ship Officer
Michael Buffer
Fight Fan #1
Bruce Buffer
Fight Fan #2
Russell Wilcox
Announcer
Hector Bateman-Harden
Young Sherlock Holmes
Codie-Lei Eastick
Young Watson
Laura Stevely
Sherlock's Mother
Sadie Newman
Jane
Ella Bright
Bridgette
Paul Bigley
Teacher #1
Sue Maund
Teacher #2
Tommy Gene Surridge
Inky Hands
Paddy Holland
Tough Kid
Hugh Laurie
Mycroft Holmes (uncredited)
Steve Coogan
Gustav Klinger (uncredited)
Phil Hodges
Mr. Algernon Barkworth (uncredited)
Sara Beasley
Mrs. Frobisher (uncredited)
James Eeles
Manager Mr. Petrucka (uncredited)
Paul T.T. Easter
John (uncredited)
Jordan Long
Herbert (uncredited)
Riley White
Newsie Kid - Jimmy (uncredited)
Lochlan White
Newsie Kid - Timmy (uncredited)
Martin Bassindale
One Man Band (uncredited)
Karl Farrer
Russian Merchant (uncredited)
Jorge Leon
British Soldier (uncredited)
Martyn Mayger
Buckingham Palace Guest (uncredited)
Deepak Anand
Nobleman (uncredited)
Shawn Dixon
Upper Class Gentleman #1 (uncredited)
