Tom Cruise
Frank T.J. Mackey
Philip Baker Hall
Jimmy Gator
Philip Seymour Hoffman
Phil Parma
Julianne Moore
Linda Partridge
William H. Macy
Quiz Kid Donnie Smith
John C. Reilly
Officer Jim Kurring
Melora Walters
Claudia Wilson Gator
Jeremy Blackman
Stanley Spector
Jason Robards
Earl Partridge
Melinda Dillon
Rose Gator
Michael Bowen
Rick Spector
April Grace
Gwenovier
Ricky Jay
Burt Ramsey / Narrator
Pat Healy
Sir Edmund William Godfrey / Young Pharmacy Kid
Neil Flynn
Stanley Berry
Rod McLachlan
Daniel Hill
Allan Graf
Firefighter
Patton Oswalt
Delmer Darion
Brad Hunt
Craig Hansen
Jim Meskimen
Forensic Scientist
Chris O'Hara
Sydney Barringer
Clement Blake
Arthur Barringer
Jim Ortlieb
Middle-Aged Guy
Thomas Jane
Young Jimmy Gator
Veronica Hart
Dentist Nurse #1
James Kiriyama-Lem
Dr. Lee
Cleo King
Marcie
Don McManus
Dr. Landon
Michael Shamus Wiles
Captain Muffy
John S. Davies
Cameraman
Kevin Breznahan
Geoff, Seminar Guy
Miguel Pérez
Avi Solomon
Alfred Molina
Solomon Solomon
Neil Pepe
Officer #1
Lionel Mark Smith
Detective
Annette Helde
Coroner Woman
Felicity Huffman
Cynthia
Scott Burkett
WDKK Page #1
Danny Wells
Dick Jennings
Eileen Ryan
Mary
Meagen Fay
Dr. Diane
Luis Guzmán
Luis
Orlando Jones
Worm
Henry Gibson
Thurston Howell
Natalie Elizabeth Marston
Julia
Clark Gregg
WDKK Floor Director
Matt Gerald
Officer #2
Paul F. Tompkins
Chad (Seduce & Destroy) (voice)
Mary Lynn Rajskub
Janet (Frank's Assistant) (voice)
Jim Beaver
Smiling Peanut Patron #1
Ezra Buzzington
Smiling Peanut Patron #2
Michael Murphy
Alan Kligman, Esq.
Robert Downey Sr.
WDKK Show Director
William Mapother
WDKK Show Director's Assistant
Lillian Adams
Donnie's Old Neighbor
Dale Gibson
Paramedic #3
Scott Alan Smith
E.R. Doctor
Paul Thomas Anderson
Man Confiscating Sign (uncredited)
Miriam Margolyes
Faye Barringer (uncredited)
Robert Bella
Detective #2 (uncredited)
Greg Bronson
Waiter (uncredited)
Phil Hawn
Bob (uncredited)
Spencer Kayden
Seminar Patron (uncredited)
Aimee Mann
Hot Date Infomercial (uncredited)
Tom Ohmer
Detective (uncredited)
