Whoopi Goldberg
Ranger Margaret (voice)
David Spade
Ranger Frank (voice)
E. G. Daily
Tommy Pickles (voice)
Tara Strong
Dilan "Dil" Pickles (voice)
Christine Cavanaugh
Chuckie Finster (voice)
Kath Soucie
Phil / Lil / Betty DeVille (voices)
Cheryl Chase
Angelica Pickles (voice)
Tim Curry
Rex Pester (voice)
Jack Riley
Stuart 'Stu' Pickles (voice)
Busta Rhymes
Reptar Wagon (voice)
Michael Bell
Charles 'Chaz' Finster Sr. / Grandpa Boris Kropotkin / Drew Pickles (voice)
Joe Alaskey
Grandpa Lou Pickles (voice)
Phil Proctor
Howard DeVille / Igor (voice)
Cree Summer
Susie Carmichael (voice)
Tress MacNeille
Charlotte Pickles (voice)
Melanie Chartoff
Didi Pickles / Minka Kropotkin (voice)
Hattie Winston
Lucy Carmichael (voice)
Andrea Martin
Aunt Miriam (voice)
Tony Jay
Dr. Lipschitz (voice)
Abraham Benrubi
Serge (voice)
Gregg Berger
TV Announcer (voice)
Charlie Adler
United Express Driver (voice)
Mary Gross
Female Guest (voice)
Edie McClurg
Nurse (voice)
Roger Clinton, Jr.
Air Crewman (voice)
Margaret Cho
Lt. Klavin (voice)
Iggy Pop
Newborn Baby (singing voice)
Lisa Loeb
Newborn Baby (singing voice)
Lenny Kravitz
Newborn Baby (singing voice)
Dawn Robinson
Newborn Baby (singing voice)
Lou Rawls
Newborn Baby (singing voice)
Kate Pierson
Newborn Baby (singing voice)
Cindy Wilson
Newborn Baby (singing voice)
Gordon Gano
Newborn Baby (singing voice)
Laurie Anderson
Newborn Baby (singing voice)
Jakob Dylan
Newborn Baby (singing voice)
Patti Smith
Newborn Baby (singing voice)
Beck
Newborn Baby (singing voice)
Steve Zirnkilton
Reporter (voice)
Frank Welker
Spike / Monkeys / Scar Snout (voice) (uncredited)
Phife Dawg
Newborn Baby (Singing Voice)
